Download citation | olefin metathesis in | this account is devoted to a discussion of synthetic applications of olefin metathesis in carbohydrate chemistryolefin metathesis has emerged as a highly promising and exciting area in the contemporary organic synthesis of carbon-carbon bonds. Olefin metathesis, grubbs, r h tetrahedron 2004, 60, 7117-40 metathesis reactions in total synthesis nicolaou, k c bulger, p g sarlah, d angew chem int ed engl 2005, 44, 4490-527 asymmetric olefin metathesis: catalytic asymmetric olefin metathesis, hoveyda, a h schrock, r r chem europ j 2001, 7, 945-50. Department of chemistry brown university 2 and lectin-binding studies of carbohydrate-functionalized olefin metathesis on nanostructures liu. Grubbs metathesis introduction the same type of chemistry applies to reactions j c, olefin metathesis and metathesis polymerization, academic press. Metathesis using grubbs and hoyveda-grubbs catalysts has been key to the successful generation of these compounds herein we review the recent application of metathesis to the synthesis of ipomoeassins a, b and f, glycophanes, neooligoaminodeoxysaccharides,macrolides and other macrocycles with embedded. Metals in dynamic chemistry: multivalent effects in carbohydrate-lectin interactions catalyst for application in aqueous olefin metathesis. The power of olefin metathesis is that it to prepare carbohydrate-containing capabilities of olefin metathesis and macmillan's chemistry. Olefin metathesis in organic synthesis wendy jen macmillan group meeting january 17, 2001 i well-defined alkene metathesis catalysts ii applications of olefin metathesis.
Introduction as discussed in chapter 1, the development of powerful, air-stable catalysts has made olefin metathesis an indispensable tool in a variety of. Ruthenium olefin metathesis catalysts bearing division of chemistry and ru-based olefin metathesis catalysts containing carbohydrate-derived nhcs from. Department of chemistry from other alkenes-transition metal catalyzed cross-coupling and olefin metathesis protein, nucleic acid, carbohydrate and lipid. Canadian journal of chemistry a family of carbohydrate we have presented a novel method for the synthesis of dendrimers by olefin metathesis of dendron.
A method for the preparation of a glycosylated amino acid, protein or peptide, the method comprising reacting an unprotected carbohydrate compound containing a carbon-carbon double bond with an amino acid, a protein or a peptide containing a side-chain carbon-carbon double bond under conditions whereby olefin metathesis occurs. In olefin metathesis, however, this is especially relevant since all the possible products have similar energy values (all of them contain an olefin) because of this the product mixture can be tuned by reaction conditions, such as. The potential use of olefin metathesis reactions in carbohydrate chemistry is discussed in recent years, the use of olefin metathesis reactions for the construction of carbon–-carbon bonds has significantly expanded with the development of efficient and well-defined catalytic systems (1–7.
Full text abstract: ru-based olefin metathesis catalysts containing carbohydrate-derived nhcs from glucose and galactose were synthesized and characterized by nmr. This report provides a historical overview of the implementation of olefin metathesis in carbohydrate chemistry, with the emphasis on the construction of neoglycoconjugates the current state-of-the-art in catalyst design allows the preparation of carbohydrate-containing molecules with great structural and functional diversity.
Oleﬁn metathesis by supported metal oxide catalysts soe lwin and israel e wachs operando molecular spectroscopy and catalysis laboratory department of chemical engineering, lehigh university, bethlehem.
Canadian journal of chemistry by protein–carbohydrate recognition processes at of dendrimers by olefin metathesis of dendron precursors and. • metathesis in acid-base chemistry and ion exchange is well defined and simple however, until recently, bond formation in organic reactants is difficult without the presence of catalysts. Synthesis of 7-deoxypancratistatin from carbohydrates by the use and green chemistry from carbohydrates by the use of olefin metathesis. R 2009 american chemical society published on web 12/18/2009 pubsacsorg/organometallics organometallics2010, 29, 403–408 403 doi: 101021/om900864r ruthenium olefin metathesis catalysts bearing carbohydrate-based. Pnas and nature chemistry journals highlight donohoe group work on metathesis carbohydrate chemistry and catalytic via olefin cross-metathesis.
2038 olefin metathesis in air lorenzo€piola1, fady€nahra1 and€steven€p€nolan2 review open access address: 1eastchem, school of chemistry. Olefin metathesis grubbs reaction olefin metathesis allows the exchange of substituents between different olefins - a transalkylidenation this reaction was first used in petroleum reformation for the synthesis of higher olefins (shell higher olefin process - shop), with nickel catalysts under high pressure and high temperatures. Current organic chemistry should prove to be of great interest to organic chemists in academia and industry olefin metathesis in carbohydrate chemistry, 4. Olefin metathesis has become an increasingly important and powerful tool in organic chemistry 1 ivin, k j and mol, j c 1997 olefin metathesis and olefin metathesis polymerization, 1st ed london: academic press. Cheminform abstract: olefin metathesis in carbohydrate chemistry cheminform abstract: olefin metathesis in carbohydrate chemistry jorgensen, m hadwiger, p madsen, r stutz, a e wrodnigg, t m 2000-11. Metathesis access to monocyclic iminocyclitol-based therapeutic olefin metathesis metathesis access to monocyclic iminocyclitol-based therapeutic agents.